화학생명융합연구센터

화학생명융합연구센터는 의공학 및 의약학 분야의 다학제간 융·복합 연구를 통해, 암을 포함해 난치성 질환을 조기에 정확히 진단하고 환자 맞춤치료를 구현할 수 있는 최첨단 진단·치료 기술 개발을 목표로 하고 있습니다. 본 연구센터는 ‘분자영상 (Molecular Imaging)’ 및 ‘나노의학 (Nanomedicine)’ 기술의 융·복합 기술개발에 필요한 바이오·나노 원천소재를 발굴하고, 혁신 신약탐색연구를 수행함으로써 글로벌 경쟁력 확보가 가능한 미래 의학 원천기술을 확보하고 국내 연구역량을 세계적 수준으로 발전시키고자 합니다.

김세훈
화학생명융합연구센터장

주요

Photoechogenic Inflatable Nanohybrids for Upconversion-Mediated Sonotheranostics. ACS Nano. 2021; doi: 10.1021/acsnano.1c07898. (IF 15.881)
Statin-mediated inhibition of RAS prenylation activates ER stress to enhance the immunogenicity of KRAS mutant cancer. J Immunother Cancer. 2021;9(7):e002474 (IF 13.751)
Xenogenization of tumor cells by fusogenic exosomes in tumor microenvironment ignites and propagates antitumor immunity. Sci Adv. 2020;6(27):eaaz2083 (IF 14.143)
Injectable Single-Component Peptide Depot: Autonomously Rechargeable Tumor Photosensitization for Repeated Photodynamic Therapy. ACS Nano. 2020;14(11):15793 (IF 15.881)
Kidney-Targeted Cytosolic Delivery of siRNA Using a Small-Sized Mirror DNA Tetrahedron for Enhanced Potency. ACS Cent Sci. 2020;6(12):2250 (IF 14.553)
Degradation of tumour stromal hyaluronan by small extracellular vesicle-PH20 stimulates CD103+ dendritic cells and in combination with PD-L1 blockade boosts anti-tumour immunity. J Extracell Vesicles. 2019;8(1):1670893 (IF 25.841)
Water-soluble phthalocyanines selectively bind to albumin dimers: A green approach toward enhancing tumor-targeted photodynamic therapy. Theranostics. 2019;9(22):6412 (IF 11.556)
Highly tumor-specific DNA nanostructures discovered by in vivo screening of a nucleic acid cage library and their applications in tumor-targeted drug delivery. Biomaterials. 2019;195:1 (IF 12.479)
Cumulative Directional Calcium Gluing between Phosphate and Silicate: A Facile, Robust and Biocompatible Strategy for siRNA Delivery with Amine-Free Non-Positive Vector. Biomaterials. 2019;209:126 (IF 12.479)
Designed trimer-mimetic TNF superfamily ligands on self-assembling nanocages. Biomaterials. 2018;180:67 (IF 12.479)
Combined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer. Nat Commun. 2018;9(1):2165 (IF 14.919)
Nanocage-Therapeutics Prevailing Phagocytosis and Immunogenic Cell Death Awakens Immunity against Cancer. Adv Mater. 2018;30(10) (IF 30.849)
Chemiluminescence Imaging of Duox2-Derived Hydrogen Peroxide for Longitudinal Visualization of Biological Response to Viral Infection in Nasal Mucosa. Theranostics. 2018;8(7):1798 (IF 11.556)
Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway. Science. 2018;362(6418):eaat0174 (IF 47.728)