Recognize Biomolecules and Beat Diseases
While the advent of the 4th industrial revolution pushed the frontiers of science to generate remarkable scientific progress, the task of overcoming challenges concerning low birthrates, ageing, new infectious diseases, and rare diseases still remain. The Advanced Biomolecular Recognition Research Center is conducting research to understand the mechanisms of disease at a molecular level and to discover the mode of action of new drugs that can be applied to the diagnosis and treatment of diseases. Furthermore, by integrating nanotechnology, IT, and artificial intelligence, we are developing sensor systems targeting biomolecular markers that can be used in a clinical setting. Through cutting edge technologies introduced with the 4th industrial revolution, we pledge to lead the innovation of new drugs, early-stage disease diagnoses, and smart healthcare for all.
Kwan Hyi Lee, Ph.D.
Head, Principal Research Scientist
Research Scope & Teams
The Advanced Biomolecular Recognition Center has three main research scopes:
1) Biomolecular engineering and control team led mechanism study of disease development and biomarker discovery.
2) Development of NT/BT/IT-based sensing and biomarker diagnostic platform led by biochemical diagnostic research team
3) Biomarker verification and treatment development through disease modeling led by the endocrine hormone function verification team and application intermediation to clinical samples
Omics is a powerful research tool for understanding disease mechanisms and drug actions in biochemical systems. The team focuses on finding steroid hormones, primary metabolites, lipids, genes and proteins as signaling molecules. Through integrated epidemiological studies of biological samples of disease models, we can uncover multiple biomarkers for reliable diagnostic tools in clinical practice.
Biomarker detection with comprehensive selectivity and sensitivity is an important aspect of disease testing. The NT/BT/IT-based biochemical diagnostic team focuses on developing simple equipment with continuous monitor ability through the development of sensing and diagnostic platforms using new nanomaterials and test kits to recognize multiple biomarkers based on field demand.
Biomarker validation in terms of molecular diagnosis and treatment is a prerequisite for shedding light on the biochemical workings of diseases and drugs. Endocrine hormone function validation teams validate biomarkers and drug action targets through disease modeling, and create stable cell lines and genome-edited animal models for mechanism research.