Hyunbeom Lee Senior Researcher






  • Northwestern University, Chemistry, Ph.D. (2014)
  • (Advisor: Dr. Richard B. Silverman)
  • – Illinois Institute of Technology, Chemistry, B.Sc. (2008)
  • KIST, Senior Research Scientist (2016~)
  • Hanyang University, HY-KIST research professor (2020~)
  • KIST, Research Scientist (2014-2016)
  • Understanding metabolic flexibility in cancers
  • Elucidating drug mechanisms through enzymology and metabolomics
  • Discovering complementary therapeutic targets for intractable metabolic diseases
  • H Lee. et al. Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase by (1S,3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115). J. Am. Chem. Soc. 137, 2628-2640, (2015).
  • al. Ornithine Aminotransferase versus GABA Aminotransferase: Implications for the Design of New Anticancer Drugs. Med. Res. Rev. 35, 286-305, (2015).
  • H. Lee. et al. Mechanism of Inactivation of GABA Aminotransferase by (E) and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid. ACS Chem. Biol.. 10, 2087-2098, (2015).
  • H. Lee. et al. Regulation of endogenic metabolites by rosuvastatin in hyperlipidemia patients: An integration of metabolomics and lipidomics. Chem. Phys. Lipids, 214, e1525243, (2018)
  • H. Kwak, W. Koh, S. Kim, K. Song,(…), H. Lee, Y. C. Bae, C. J. Lee, E. Cheong. Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus. Neuron 108(4), 691-706, (2020)J. E. Oh, B. H. Jung, J. Park, S. Kang, H. Lee. Deciphering Fatty Acid Synthase Inhibition-Triggered Metabolic Flexibility in Prostate Cancer Cells through Untargeted Metabolomics. Cells 9(11), 2447 (2020)