The Chemical and Biological integrative Research Center aims to develop cutting-edge diagnostic and treatment technologies that can accurately diagnose incurable diseases, including cancer, and implement patient-tailored treatments through multidisciplinary integrative researches in medical engineering and pharmaceutical sciences. This research center aims to secure future medical technologies for global competitiveness and develop domestic research capabilities to a global level by discovering novel bio-nano materials necessary for the development of integrative technologies of molecular imaging and nanomedicine and performing innovative drug discovery researches.
Sehun, Kim
Head, Chemical Life Convergence
Scientific
- Photoechogenic Inflatable Nanohybrids for Upconversion-Mediated Sonotheranostics. ACS Nano. 2021; doi: 10.1021/acsnano.1c07898. (IF 15.881)
- Statin-mediated inhibition of RAS prenylation activates ER stress to enhance the immunogenicity of KRAS mutant cancer. J Immunother Cancer. 2021;9(7):e002474 (IF 13.751)
- Xenogenization of tumor cells by fusogenic exosomes in tumor microenvironment ignites and propagates antitumor immunity. Sci Adv. 2020;6(27):eaaz2083 (IF 14.143)
- Injectable Single-Component Peptide Depot: Autonomously Rechargeable Tumor Photosensitization for Repeated Photodynamic Therapy. ACS Nano. 2020;14(11):15793 (IF 15.881)
- Kidney-Targeted Cytosolic Delivery of siRNA Using a Small-Sized Mirror DNA Tetrahedron for Enhanced Potency. ACS Cent Sci. 2020;6(12):2250 (IF 14.553)
- Degradation of tumour stromal hyaluronan by small extracellular vesicle-PH20 stimulates CD103+ dendritic cells and in combination with PD-L1 blockade boosts anti-tumour immunity. J Extracell Vesicles. 2019;8(1):1670893 (IF 25.841)
- Water-soluble phthalocyanines selectively bind to albumin dimers: A green approach toward enhancing tumor-targeted photodynamic therapy. Theranostics. 2019;9(22):6412 (IF 11.556)
- Highly tumor-specific DNA nanostructures discovered by in vivo screening of a nucleic acid cage library and their applications in tumor-targeted drug delivery. Biomaterials. 2019;195:1 (IF 12.479)
- Cumulative Directional Calcium Gluing between Phosphate and Silicate: A Facile, Robust and Biocompatible Strategy for siRNA Delivery with Amine-Free Non-Positive Vector. Biomaterials. 2019;209:126 (IF 12.479)
- Designed trimer-mimetic TNF superfamily ligands on self-assembling nanocages. Biomaterials. 2018;180:67 (IF 12.479)
- Combined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer. Nat Commun. 2018;9(1):2165 (IF 14.919)
- Nanocage-Therapeutics Prevailing Phagocytosis and Immunogenic Cell Death Awakens Immunity against Cancer. Adv Mater. 2018;30(10) (IF 30.849)Chemiluminescence Imaging of Duox2-Derived Hydrogen Peroxide for Longitudinal Visualization of Biological Response to Viral Infection in Nasal Mucosa. Theranostics. 2018;8(7):1798 (IF 11.556)
- Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway. Science. 2018;362(6418):eaat0174 (IF 47.728)
- Development of treatments and identification of disease-related protein structures using structural biology
- Development of protein/cell imaging technologies using nanotechnology
- Development of nano-biomaterials for diagnosis and treatments
- Development of biophotonics-based materials for diagnosis and treatments
- Development of fusion protein-based materials for diagnosis and treatments
- Discovery of disease-related biomarkers using proteomics and genomics
- Development of immunotherapies
- Small molecule drug discovery
- Identification of mechanisms of drug action using chemical biology
Chemical & Biological integrative Research Center
분자프로테오믹스 연구팀 (이철주 박사)
KIMS(KIST InterMembrane Signaling)(김인산 박사, 정철현 박사)
BNL(Biophotonics and Nanomedicine Laboratory)
