Yoon Park    Senior Researcher







2008   Ph.D. Yonsei University, Korea
2004   M.S. Yonsei University, Korea
2002   B.S. Yonsei University, Korea

2018- present  Senior research scientist/Principal Investigator
Korea Institute of Science and Technology, Seoul, Korea

2016-2018    Senior Research Investigator II – T cell Immunotherapy
Bristol-Myers Squibb, Redwood city, CA

2015-2016    Senior scientist – Allogeneic CAR-T cell therapy
Pfizer, South San Francisco, CA

2014-2015    Instructor, La Jolla Institute for Allergy and Immunology, La Jolla, CA

2009-2014    Postdoctoral Fellow, La Jolla Institute for Allergy and Immunology, La Jolla, CA

Park Y*, Jin HS*, Lopez J, Lee JH, Elly C, Liu YC. (2016) SHARPIN controls regulatory T cells by negatively
modulating the T cell antigen receptor complex. Nature Immunol. Feb 2; 17(3):286-96. (* co-First author)
* Commentary in the same issue of Nature Immunol. 2016 Feb 16; 17(3):221-2. Bowman M, et al.

Park Y, Jin HS, Lopez J, Elly C, Kim G, Murai M, Kronenberg M, Liu YC (2013) TSC1 regulates the balance
between effector and regulatory T cells. J Clin Invest. Dec 2;123(12):5165-78.
* Commentary in the same issue of J.Clin Invest 2013 Dec 2;123(12):5001-4. Yang K, et al.

Park Y, Jin HS, Liu YC (2013) Regulation of T cell function by the ubiquitin-specific protease USP9X via
modulating Carma1-Bcl10-Malt1 complex. Proc Natl Acad Sci USA. 2013 Jun 4;110(23):9433-8.

Park Y, Jin HS, Aki D, Lee JH, Liu YC (2014) The Ubiquitin System in Immune Regulation. Adv Immunol.
124:17-66 (Review)

Jin HS, Park Y, Elly C, Liu YC (2013) Itch expression by regulatory T cells controls T helper type 2 responses.
J Clin Invest. Nov 1;123(11):4923-34.
* Commentary in the same issue of J.Clin Invest 2013 Nov 1;123(11):4576-8. Chen W.
* Comment on Cell Mol Immunol. 2014 Mar;11(2):126-8. Singer BD, D’Alessio FR.

Lee JH, Elly C, Park Y, Liu YC. (2015) E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to
Maintain Regulatory T Cell Stability and Suppressive Capacity. Immunity, 16;42(6):1062-74.

Krause P, Morris V, Greenbaum JA, Park Y, Bjoerheden U, Muffley T, Shui JW, Kim G, Cheroutre H, Liu YC,
Peters B, Kronenberg M and Murai M (2015) IL-10 producing intestinal macrophages prevent excessive anti-
bacterial innate immunity by limiting IL-23 synthesis. Nat. Commun. 6:7055.

Jin HS, Liao L, Park Y, Liu YC (2013) Neddylation pathway regulates T-cell function by targeting an adaptor
protein Shc and a protein kinase Erk signaling. Proc Natl Acad Sci USA. 110(2):624-9.

Lee SH, Park Y, Yoon SK, Yoon JB (2010) Osmotic stress inhibits proteasome by p38 MAPK-dependent
phosphorylation. J Biol Chem. 285(53):41280-9.

Baranes-Bachar K, Levy-Barda A, Oehler J, Reid DA, Soria-Bretones I, Voss TC, Chung D, Park Y, Liu C, Yoon
JB, Li W, Dellaire G, Misteli T, Huertas P, Rothenberg E, Ramadan K, Ziv Y, Shiloh Y (2018)
The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage,
Facilitating Double-Strand Break Repair. Mol Cell  69(5):866-878.

Kim SE, Yoon JY, Jeong WJ, Jeon SH, Park Y, Yoon JB, Park YN, Kim H, Choi KY (2009) H-Ras is degraded by
Wnt/beta-catenin signaling via beta-TrCP-mediated polyubiquitylation. J Cell Sci. 122(Pt 6):842-8.

Park Y, Yoon SK, Yoon JB (2009) The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin fusion
degradation pathway. J Biol Chem. 284(3):1540-9.

Park Y, Yoon SK, Yoon JB (2008) TRIP12 functions as an E3 ubiquitin ligase of APP-BP1. Biochem Biophys Res
Commun. 374(2):294-8.

Park Y*, Hwang YP*, Lee JS, Seo SH, Yoon SK, Yoon JB (2005) Proteasomal ATPase-associated factor 1
negatively regulates proteasome activity by interacting with proteasomal ATPases. Mol Cell Biol. 25(9):3842-53.
(* co-First author)

Min KW, Kwon MJ, Park HS, Park Y, Yoon SK, Yoon JB (2005) CAND1 enhances deneddylation of CUL1 by
COP9 signalosome. Biochem Biophys Res Commun. 334(3):867-74.

Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB (2003) TIP120A associates with cullins and modulates
ubiquitin ligase activity. J Biol Chem. 278(18):15905-10.